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br Glioblastoma GBM is the highest
2024-06-19
Glioblastoma GBM is the highest-grade glioma (Grade IV) according to WHO classification and belongs to the most malignant form of PCI-34051 tumor. It is an incurable disease despite the use of aggressive treatments that include surgery and radiotherapy, usually in combination with chemotherapy [1
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Liaohe River situates in the southwestern
2024-06-19
Liaohe River situates in the southwestern part of Northeast China and flows through Liaoning Province. Due to the rapid urbanization and industrialization, Liaohe River has become one of the most polluted rivers in China. Multitudinous organic pollutants that can induce toxicity to organisms such as
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In conclusion the results of this investigation
2024-06-19
In conclusion, the results of this investigation suggest that the involvement of PGE2 in the pathogenesis of pulpal inflammation and repair may be related to its induction of cAMP production. PGE2-induced cAMP production in dental pulp cells is mediated by binding to the EP2 receptor, activation of
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We have previously shown that the human gonadotropins
2024-06-19
We have previously shown that the human gonadotropins hLH and hCG trigger a partly irreversible stimulation of intracellular cyclic AMP accumulation in mouse Leydig Tumor Phosphocreatine disodium salt (MLTC) in contrast to all other tested mammalian LHs and CG (Klett et al., 2016). In order to get
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Cofilin is an additional actin severing protein present in s
2024-06-19
Cofilin is an additional AZD6738 severing protein present in sperm cells that undergo phosphorylation/inactivation on serine 3 by Lim kinases (LIMK) and by Tes kinases (TESK) [48]. LIMK can be activated by several pathways, including one through the Rho/ROCK/LIMK cascade [49], [50], [51]. Another w
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It is well known that the
2024-06-19
It is well known that the thymus plays an important function in the complex pathogenesis and perpetuation of MG. We compared resistin levels between patients with MG with or without thymoma and found that those with thymoma had higher levels than those without thymoma. It has been previously recogni
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Until now there are no report regarding the relationship
2024-06-19
Until now, there are no report regarding the relationship of CD21 and MG. In the present study, we aimed to characterize the AchR specified 2 nbdg and investigated the role of CD21 in immunopathogenesis of MG. We utilized the Allophycocyanin (APC)-conjugated AchR to measure the frequencies of AchR
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Owing to efficient catalytic character
2024-06-19
Owing to efficient catalytic character, high electrolyte accessible area, easy fabrication and many other interesting properties, metal oxide nanoparticles are extensively used in a variety of electro-analytical processes [14]. Metal oxide nanoparticles immobilized over a conductive and large area s
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In this paper we describe the formation
2024-06-18
In this paper, we describe the formation of a structure-based pharmacophore which lead to the discovery of several hydrophobic, yet non-lipid inhibitors of ATX. These compounds docked within the same volume occupied by the initial non-lipid inhibitors of ATX used to build the pharmacophore. Violatio
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br The Molecular Machinery of Autophagy
2024-06-18
The Molecular Machinery of Autophagy and Regulation by Sphingolipids Sphingolipid-Mediated Autophagy in Cancer: Dr. Jekyll and Mr. Hyde Autophagy is an evolutionarily conserved stress response that typically promotes survival and antagonizes apoptosis. However, excessive autophagy was found to
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Expression of Twist and the AR are increased by oxidative
2024-06-18
Expression of Twist1 and the AR are increased by oxidative stress, but the change in the receptor (mRNA/protein) is lost after treatment with siRNAs that target Twist 1 (Shiota et al., 2010). Twist 1 was found to bind to E-boxes, 5′-CANNTG-3′, in the proximal promoter (−442 to +51 bp) and upstream r
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br Discussion Hepatic dysfunction in
2024-06-18
Discussion Hepatic dysfunction in the metabolic syndrome is a driver of negative patient outcomes that requires more therapeutic options. The complexity of liver alterations in this disease – elevated de novo synthesis of fatty acids and cholesterol, reduced clearance of circulating atherogenic L
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Introduction Induction of long term
2024-06-18
Introduction Induction of long-term potentiation (LTP), the cellular correlate of learning and memory, triggers profound changes in the structure and function of excitatory synapses by increasing dendritic spine size and synaptic strength. Significant progress has been made in understanding the int
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An issue related to research without biomarkers is that many
2024-06-18
An issue related to research without biomarkers is that many studies will ascertain some but not all biomarker groups in study participants. Because tau PET is relatively new, incomplete biomarker information will occur in studies that use imaging for amyloid and neurodegenerative biomarker characte
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Our previous study revealed expression of
2024-06-18
Our previous study revealed expression of AhR in human parotid gland in cytoplasm of striated duct osmi (Drozdzik, Kowalczyk, Urasińska, & Kurzawski, 2013). In a further study we observed regulation of AhR expression and function by its specific inducer, i.e. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCD
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