• br Conclusions In summary we

  2021-09-08

  

  Conclusions In summary, we have designed an ultrasensitive electrochemical assay for hOGG1 based on a ratiometric strategy and HCR assisted amplification. The hOGG1 can specifically identify 8-oxo G site on the DNA probes modified on the electrode surface. The subsequent cleavage reaction trigger

• The association between mental disorders and

  2021-09-08

  

  The association between mental disorders and smoking was firmly established, and their inter-relationship was due to the reciprocal causal effects (Tjora et al., 2014). Previous research found that negative affect and the urge to smoke as well as the urge to smoke and nicotine dependence had signifi

• Transmembrane AMPA receptor regulatory proteins

  2021-09-08

  

  Transmembrane AMPA receptor regulatory proteins (TARPs) are a relatively newly discovered protein family. Prototypic TARP, stargazin, was found by a spontaneous mutation in ataxic stargazer mouse line as a homologous protein to γ1 calcium channel subunit (Letts et al., 1998). The role of stargazin i

• br Sodium glucose co transporter inhibitors

  2021-09-08

  

  Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are the latest class of non-insulin glucose-lowering agents that facilitate glycaemic control by inhibiting renal glucose reabsorption, thus promoting glycosuria. Canagliflozin, dapagliflozin, and empagliflozin are the three commonly used agents

• It is increasingly argued that the immunosuppressive effects

  2021-09-08

  

  It is increasingly argued that the immunosuppressive effects of GCs are conferred indirectly by GR through the activation of genes encoding proteins that inhibit 3,3',5'-Triiodo-L-thyronine of proinflammatory genes 86, 87, 88. Genomic studies offer another mechanism compatible with the idea that GC

• Natural product based drug discovery can be enhanced

  2021-09-08

  

  Natural-product-based drug discovery can be enhanced with computational methods [205]. Because most of the reported small-molecule natural inhibitors of fMLF-induced functional responses were not evaluated in 3463 australia binding assays, we used molecular modeling to predict how well these compou

• Over the years a number of studies have

  2021-09-07

  

  Over the years, a number of studies have reported results concerning the behavior of the two endothelin receptor subtypes, ETA and ETB, that do not fit the classical model of two G protein-coupled receptors acting independently of one another. For example, in the rat anterior pituitary gland, both E

• Certainly the immune relevance of Hippo becomes more complic

  2021-09-07

  

  Certainly, the immune relevance of Hippo becomes more complicated and divergent in the vertebrates than in Drosophila. In terms of inflammation of mammalians, the stories are diversified (Fig. 2). Previously, MST1/2 has been well characterized not only as a controller of lymphocytes adhesion and mi

• The Hardy Weinberg equilibrium was verified in

  2021-09-07

  

  The Hardy-Weinberg equilibrium was verified in all groups using the chi-square test. Using WINPEPI 11.65, the number of carriers and non-carriers of the Δ32 allele was compared between the groups through the Pearson's chi-square test with Yates's correction. Two-tailed Fisher's test was used when ap

• Modulation of the cannabinoid system has

  2021-09-07

  

  Modulation of the cannabinoid system has been reported to exert anti-parkinsonian properties through different mechanisms. On one hand, cannabinoids have neuroprotective properties in different rodent models of PD, both through a CB1/CB2 receptor-independent mechanism (Lastres-Becker et al., 2005) a

• The HIV genome encodes for a

  2021-09-07

  

  The HIV-1 genome encodes for a variety of viral proteins necessary for target cell entry and viral replication. gp120 is an HIV-1 envelope glycoprotein that mediates viral particle entry by binding to cell surface receptor CD4 and co-receptors CXCR4 and/or CCR5 depending on viral tropism. While CXCR

• In our study we evaluated adenovirus type Ad

  2021-09-07

  

  In our study we evaluated adenovirus type 5 (Ad5) as a vehicle for delivering Cre recombinase in conditional transgenic mouse based on the Cre-loxP system, in order to achieve GlyT1 gene modulation in a specific thalamic region in the adult animal. GlyT1 is a sodium- and chloride-coupled glycine tra

• There were significant differences in

  2021-09-07

  

  There were significant differences in mRNA expression levels observed for 7 out of 15 analyzed genes. This observation suggests, that selection of a reference/control group may influence interpretation of gene expression studies performed in liver pathologies. This study directly evidenced that anal

• BCCA occlusion followed by reperfusion injury significantly

  2021-09-07

  

  BCCA occlusion, followed by reperfusion injury, significantly increased the brain AT1 and AT2 receptor expression in mice. Reports have demonstrated elevation of AT1 receptor expression in the cerebral NVP-AEE788 during ischemia [34,35]. The gene expression of brain AT2 receptor is increased in both

• BG45 Here we examined whether complete ablation of GIP produ

  2021-09-07

  

  Here, we examined whether complete ablation of GIP production could reduce weight gain in the absence of the adipocyte hormone leptin, a condition that results in extreme hyperphagia, obesity, hyperinsulinemia, and insulin resistance, in both mice [24] and humans [25]. We found that Lepob/ob mice be

14567 records 572/972 page Previous Next First page 上5页 571572573574575 下5页 Last page