• Endoplasmic reticulum ER stress resulting from

  2024-08-17

  

  Endoplasmic reticulum (ER) stress resulting from accumulation of misfolded proteins in ER lumen stimulates a chain of adaptive responses termed as the unfolded protein response (UPR). Glucose related protein (GRP78/BiP), key ER chaperone essential for the activation of the ER-transmembrane signaling

• In considering the roles of these enzymes in

  2024-08-17

  

  In considering the roles of these enzymes in normal physiology, given the importance of GLUT4-dependent glucose uptake and glucose-dependent fatty 3,4-DAA synthesis for systemic metabolic homeostasis (Herman and Kahn, 2006, Herman et al., 2012), deletion of Acly in adipocytes results in a surprising

• We used the lead compound C

  2024-08-17

  

  We used the lead compound C4 to demonstrate that small molecule ACL inhibitors can recapitulate ACL knockdown (KD) in modulation of cancer stemness. We have shown previously that ACL KD reduced the CSC population in multiple cancer cell lines. The E-snail cells are an established CSC model system.

• br Experimental protocols br Results and

  2024-08-17

  

  Experimental protocols Results and discussion Conclusion 15-LOX-1 is an important mammalian lipoxygenase which plays an important role in the biosynthesis of leukotrienes, lipoxins and other signalling molecules. These signalling molecules play a regulatory role in several respiratory disea

• br The role of apelin in

  2024-08-17

  

  The role of apelin in hepatic diseases The involvement of the apelin/APJ system in liver physiology and pathology has been proven in numerous studies (Table 6). For instance, in the experiment of Emam et al. [63] on rats suffering from hepatic injury, apelin decreased the levels of ALT, AST and L

• br Conclusions The present protocol for localizing or

  2024-08-17

  

  Conclusions The present protocol for localizing or “spotting” the site of action of an antioxidant in a micro-heterogeneous medium is based on the differences in its reactivity vis-à-vis the series of amphiphobic TEMPO derivatives 1a–f. Plots of the relative antioxidant effectiveness of a given A

• In Pham et al employed the microsphere

  2024-08-16

  

  In 2014, Pham et al. [22] employed the microsphere-based technology to create a Luminex probe-based assay for the rapid identification of single nucleotide polymorphisms that are known to confer resistance to one or more echinocandins in C. glabrata. The targets for the FKS probes were generated usi

• Among all the polysaccharide derivatives cationic carbohydra

  2024-08-16

  

  Among all the polysaccharide derivatives, cationic carbohydrate polymers such as quaternary ammonium salts and quaternary phosphonium salts have been the most popular and most efficient target Amidepsine A sale in medical applications [24] and water treatment [25]. Recently, quaternary phosphonium

• br Introduction Alzheimer s disease AD is a neurodegenerativ

  2024-08-16

  

  Introduction Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia. It is characterized by progressive and irreversible damage to different Biocytin mg areas, resulting in cognitive impairment and behavioral changes (O'Neill, 2013, De Strooper and Karran, 201

• A disfun o cognitiva p s operat ria uma s

  2024-08-16

  

  A disfunção cognitiva pós‐operatória é uma síndrome perioperatória bem reconhecida, consequência da anestesia e cirurgia cuja causa exata permanece por esclarecer. De que forma EIPA mg disfunção cognitiva pós‐operatória e a doença de Alzheimer podem estar ligadas permanece uma questão em estudo. A b

• br Disclosure br Acknowledgments br

  2024-08-16

  

  Disclosure Acknowledgments Introduction Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase, belongs to the insulin receptor kinase subfamily [1]. Oncogenic activation of ALK is associated with the Fmoc-Arg(Pbf)-OH and progression of multiple human cancer types [2,3], including ana

• Introduction Inflammasomes are large cytosolic protein compl

  2024-08-16

  

  Introduction Inflammasomes are large cytosolic protein complexes with multiple components that trigger a rapid immune response against pathogen-associated molecular pattern Cy5 RNA (PAMPs) during pathogen infections or damage-associated molecular pattern molecules (DAMPs) during tissue damage [1].

• The present study determined the effect of

  2024-08-16

  

  The present study determined the effect of DCA on VSMC calcification in vitro and in atherosclerotic ApoE-/- mice in vivo. We found that gssg non-toxic concentrations of DCA, did not affect VSMC viability, induced calcification of VSMC in culture and increased atherosclerotic vascular calcification

• Perhaps the discovery of this

  2024-08-16

  

  Perhaps the discovery of this linkage has served to catapult much of the work on ABCA1, leaving its family member in need of a relationship with a defined human pathology. In this regard, there is by now a quite mature literature that suggests that ABCA2 may have been overlooked in terms of its impo

• Ketogenic diets are more effective in promoting weight loss

  2024-08-16

  

  Ketogenic diets are more effective in promoting weight loss than conventional caloric restriction [26] however, their effect on hepatic glucose and lipid metabolism remains inconclusive. Blood glucose homeostasis is tightly regulated. In both mice and humans consuming KD, baseline blood glucose decr

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